ZHANG Li-He（CHANG Li-ho）
University Education:
1964-1967 Graduate School, Beijing Medical College, Major in Med. Chem.
1954-1958 Department of Pharmacy, Beijing Medical College, China
Professional Experience:
2006-date President, Academic Committee of State Key Laboratory of Natural & Biomimetic Drugs,
Peking University
2000-date Professor of Medicinal Chemistry, Peking University
1992-2006 Director, State Key Laboratory of Natural and Biomimetic Drugs, Peking University
1998-2006 Director, Chemistry Department, National Natural Science Foundation of China
1986-2000 Dean, Professor of Medicinal Chemistry, School of Pharmaceutical Sciences,
Beijing Medical University
1983-1986 Associate Professor, School of Pharmaceutical Sciences, Beijing Medical University
1981-1983 Research Associate, Department of Chemistry, University of Virginia, USA
1967-1981 Lecturer, Department of Pharmacy, Beijing Medical College
1958-1964 Assistant, Department of Pharmacy, Beijing Medical College
Research Areas:
Chemistry of Nucleosides and Nucleotides;
Anticancer and Antiviral Drugs;
Natural Products.
Scientific Society & other committee activities:
Titular Member, IUPAC, Division III, Biomolecular Chemistry Committee (2006-2008);
Fellow, Royal Society of Chemistry ( 2006-);
Member, Chinese Chemical Society;
Vice-President, Chinese Pharmaceutical Association(1997-2001);
President, Asian Federation for Medicinal Chemistry(1998-2000)
Editorial Boards:
Member, Internat. Adv. Editorial Board, Organic & Biomolecular Chemistry (2006-), ChemMedChem (2007-), Medicinal Research Review (2004-), Current Topics of Medicinal Chemistry (2000-).
Awards:
2009 Nagai-Hisamitsu Outstanding Science Award, Asia Pharmaceutical Association, Kyoto, Japan
2004 Natural Science Award, Second Prize, Ministry of Science and Technology. China
2002 Science and Technology Award, Second Prize, awarded by The Ministry of Education, China
2000 Millennium Pharmaceutical Scientist Award, FIP, San Francisco, USA
1999 He-Liang-He-Li Prize
1998 Science and Technology Award, First Prize, awarded by The Ministry of Education, China
1996 Science and Technology Award, Second Prize, awarded by The Ministry of Education, China
1995 Member, Chinese Academy of Sciences
1993 12th Edgar Snow Professorship, awarded by Edgar Snow Foundation and University of Missouri,
Kansas City, USA
1993 Colorcon Award, International Symposium of International Pharmaceutical Association, Tokyo, Japan
1990 Honorary Doctorate, Hoshi University, Japan
1988 Otani Prize, awarded by Hoshi University, Japan
1980 Beijing Science and Technology Prize, awarded by Beijing City Government, China
1964 National Award for Scientific Research Excellence, State Commission Science & Technology, China
Publications; over 250 in refereed journals.
Nucleic Acids Res. 2002, 30 (13), 3005-3014; Bioconjugate Chem., 2003, 14 (3), 532-538; J. Med. Chem., 2004, 47, 5674-5682; J. Cell Science, 2004, 117, 2141-2149; J. Biol. Chem., 2005, 280, 15952-15959; J. Med. Chem., 2006, 49 (19), 5501-12; Medicinal Research Reviews, 2007, 27 (3), 279-316; J. Org. Chem., 2008, 73, 3630; Synlett, 2008, 13, 1985.
Selected Publications:
1. Synthesis and biological evaluation of novel neamine–nucleoside conjugates potentially targeting to RNAs. Yanli Xu, Hongwei Jin, Zhenjun Yang, Liangren Zhang, Lihe Zhang, Tetrahedron, 2009, 65, 5228-5239.
2. Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs. Huang Huang, Renping Qiao, Deyao Zhao, Tong Zhang, Youxian Li, Fan Yi, Fangfang Lai, Junmei Hong, Xianfeng Ding, Zhenjun Yang, Lihe Zhang, Quan Du, and Zicai Li, Nucleic Acids Res., 2009, 37 (22), 7560-7569.
3. A method for detecting and preventing negative RNA interference in preparation of lentiviral vectors for siRNA delivery. Demin Zhou, Jing Zhang, Cuiying Wang, J. Bliesath, Qiuchen He, Dehua Yu, Lihe Zhang and F. Wong-Staal, RNA, 2009,
