理学博士，副教授，硕士生导师

办公电话: +86-10-82805281 电子邮箱: yanniu@bjmu.edu.cn

学习经历

2015.9-2016.9 德国康斯坦茨大学化学生物学与药理学系    访问学者

2013.8- 今      北京大学药学院   488365.com     副教授，硕士生导师;

2007.8-2013.7 北京大学药学院   488365.com      讲师;

2002.9-2007.7 北京大学药学院   化学生物学专业   博士;

1998.9-2002.7 北京大学药学院    药学专业       本科。

讲授课程

《药物化学》、《药物化学进展》、《计算机辅助药物设计》。

研究方向与兴趣

1.  药物先导化合物的发现和优化；

2.  基于靶标结构的药物分子设计与化学合成；

3.  活性小分子构效关系研究

获得奖励

1. 2008年  药学院第八届青年教师教学演示竞赛  二等奖

2. 2009年  北京大学医学部    优秀教师奖

3. 2010年   北京大学优秀班主任  二等奖

4. 2010年   北京大学药学院    优秀共产党员

代表性论文

Gang Yan, Lina Hao, Yan Niu*, Wenjie Huang, Wei Wang, Fengrong Xu, Lei Liang, Chao Wang, Hongwei Jin, Ping Xu*, 2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies, European Journal of Medicinal Chemistry , 2017, 137: 462–475

Jing Sun, Yan Niu*, Chao Wang, Hao Zhang, Bingyu Xie, Fengrong Xu, Hongwei Jin, Yihong Peng, Lei Liang, Ping Xu*, Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents, Bioorganic & Medicinal Chemistry , 2016, 24: 3472–3482

Qi Sun, Bo Xu, Yan Niu*, Fengrong Xu, Lei Liang, Chao Wang, Jiapei Yu, Gang Yan, Wei Wang, Hongwei Jin*, Ping Xu*. Synthesis, Bioactivity, Docking and Molecular Dynamics Studies of Furan-Based Peptides as 20S Proteasome Inhibitors. ChemMedChem , 2015, 10, 498–510.

Peng Liu, Yan Niu,* Chao Wang, Qi Sun, Yaya Zhai, Jiapei Yu,Jing Sun, Fengrong Xu, Gang Yan, Wenjie Huang, Lei Liang, Ping Xu*, 4-Oxo-1,4-dihydroquinoline-3-carboxamides as BACE-1 inhibitors: synthesis, biological evaluation and docking studies,  European Journal of Medicinal Chemistry.  2014, 79: 413- 421.

Chao Wang, Hao Zhang, Fengrong Xu, Yan Niu*, Yun Wu, Xin Wang, Yihong Peng,Jing Sun, Lei Liang and Ping Xu* , Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents,  Molecules , 2013, 18, 6057-6091.

Yan Niu, Haifei Gao, Fengrong Xu, Lei Liang, Peng Liu, Chao Wang, Guanyu Yang, Qi Sun, Ping Xu*, Design, synthesis and in vitro biological evaluation of 3-styrylbenzimidamides as potential BACE1 inhibitors,  Letters in Drug Design & Discovery , 2013, 10 ( 4 ): 297-302

Yan Niu, Haifei Gao, Fengrong Xu, Chao Wang, Peng Liu, Guanyu Yang, Qi Sun, Ping Xu*, Synthesis, in vitro biological evaluation and molecular docking studies of benzimidamides as potential BACE1 inhibitors,  Chem Biol Drug Des , 2012, 80: 775–780

Yan Niu, Chao Ma, Hongwei Jin, Fengrong Xu, Haifei Gao, Peng Liu, Yongjian Li, Chao Wang, Guanyu Yang and Ping Xu*, The Discovery of Novel b-Secretase Inhibitors: Pharmacophore Modeling, Virtual Screening, and Docking Studies,  Chem Biol Drug Des , 2012, 79:972-80

Dong Wang, Liguo Yang, Jingjing Su, Yan Niu, Xiaoping Lei, Juan Xiong, Xiaohua Cao, Yinghe Hu, Bing Mei, Jin-Feng Hu, Attenuation of neurodegenerative phenotypes in Alzheimer-like presenilin1/presenilin 2 conditional double knockout mice by EUK1001, a promising derivative of xanomeline,  Biochemical and Biophysical Research Communications , 2011, 410: 229–234

Yan Niu, Yuehua Wang, Xiaomin Zou, Xiaoming Yang, Chao Ma, Yang Lü, Bo Zhou, Yue Yuan, Guanhua Du and Ping Xu*. Synthesis and preliminary evaluation of peptidomimetic inhibitors of human β-secretase.  European Journal of Medicinal Chemistry.  2010, 45: 2089–2094

Bo Zhou, Yan Niu, Xiao-Min Zou, Feng-Rong Xu, Yue Yuan, Chao Wang, Hai-Fei Gao, Peng Liu, Ping Xu*, Structure-based design of hexahydropyrimidin-5-ols as novel non-peptidic β-secretase inhibitors,  Journal of Chinese Pharmaceutical Sciences , 2010, 19 (5): 391-400.

Wen Si, Xuliang Zhang, Yan Niu, Huiting Yu, Xiaoping Lei, Huanxin Chen, Xiaohua Cao, A novel derivative of xanomeline improves fear cognition in aged mice,  Neuroscience Letters , 2010, 473: 115–119

Yihui Cui, Dong Wang, Wen Si, Wen Lu, Yan Niu, Xiaoping Lei, Yinhe Hu, Xiaohua Cao*, Enhancement of memory function in aged mice by a novel derivative of xanomeline,  Cell Research , 2008: 1-3

中国专利

(1) 徐萍，彭宜红，王超，牛彦，张浩，许凤荣，具有MEK抑制功能的化合物及其制备方法与应用，2015.11.18-2035.11.19，中国，CN201210440137.X

(2) 徐萍，牛彦，高海飞，许凤荣，具有β-分泌酶抑制功能的化合物及其制备方法与应用，2013.4.3-2031.9.20，中国，CN201110279736.3