Lei Liang
PhD, Associate Professor
Tel：+86-10-82801505 Email：leiliang@bjmu.edu.cn
Education Experience
2000.9-2004.7 College of Chemistry, Sichuan University（BS）
2004.9-2007.3 College of Chemistry, Sichuan University（MS）
2007.4-2008.4 Department of Chemistry, University of Illinois at Urbana-Champaign (Joint Ph.D. student)
2008.5-2009.7 College of Chemistry, Sichuan University (PhD)
Work Experience
2009.7-2011.6 College of Chemistry and Molecular Engineering, Peking University (Postdoc)
2011.7-2014.7 School of Pharmaceutical Sciences, Peking University
2014.8-present Associate professor, School of Pharmaceutical Sciences, Peking University
Teaching course
Medicinal Chemistry
Experimental Medicinal Chemistry
Research
1. Drug design and synthesis
2. Rational design of molecular probe
3. Methodology of organic synthesis
Publication
1. Guanyu Yang, Qi Sun, Chao Wang,Lei Liang,* Fengrong Xu, Yan Niu, Ping Xu,* Design, synthesis and biological evaluation of sulfonamide flavone derivatives as potential 20S proteasome inhibitors. J. Chin. Pharm. Sci. 2014, 23 (9), 626–630;
2. Wei Wang, Lei Liang,* Fengrong Xu, Wenjie Huang, Yan Niu, Qi Sun, Ping Xu,* Ruthenium-Catalyzed Switchable N–H/C–H Alkenylation of 6-Phenyl(dihydro)pyridazinones with Alkynes. Eur. J. Org. Chem. 2014, 6863–6867;
3. Lei Liang, Wei Wang, Jun Wu, Fengrong Xu, Yan Niu, Bo Xu*, Ping Xu*, Rational Design, Green Synthesis, and Initial Evaluation of a Series of Full-Color Tunable Fluorescent Dyes Enabled by the Copper-Catalyzed N-Arylation of 6-Phenyl Pyridazinones and Their Application in Cell Imaging. Chem. Eur. J. 2013, 19, 13774-13782;
4. Lei Liang, Wei Wang, Fengrong Xu, Yan Niu, Qi Sun, Ping Xu*, Relay Catalysis by a Multifunctional Cu Catalyst in a Tandem Dehydro-/Dehalogenation Sequence along with N-Arylation. Org. Lett, 2013, 15, 2770-2773;
5. Lei Liang, Guanyu Yang, Fengrong Xu, Yan Niu, Qi Sun, Ping Xu*, A Copper-Catalyzed Aerobic Cascade Dehydrogenative Dehalogenative Reaction. Adv. Syn&Cat, 2013, 355, 1284-1290;
6. Lei Liang, Guanyu Yang, Fengrong Xu, Yan Niu, Qi Sun, Ping Xu*, Copper-Catalyzed Aerobic Dehydrogenation of C–C to C=C Bonds in the Synthesis of Pyridazinones. Eur. J. Org. Chem. 2013, 6130–6136;
7. Y.-B. Cai, Lei Liang, J. Zhang*, H.-L. Sun, and J.-L. Zhang*, μ-Hydroxyl trinuclear copper(II) clusters: reactivity and unusual formation in the three-component synthesis of 1,2,3-triazoles in aqueous media. Dalton Trans., 2013, 42, 5390-5400;
8. Lei Liang, H. Lv, Y. Yu, P. Wang, J.-L. Zhang *, Iron(III) tetrakis(pentafluorophenyl)porpholactone catalyzes nitrogen atom transfer to C=C and C-H bonds with organic azides. Dalton Trans., 2012, 41, 1457-1460;
9. D. K. Garner, Lei Liang, D. A. Barrios, J.-L. Zhang *, Y. Lu*, The Important Role of Covalent Anchor Positions in Tuning Catalytic Properties of a Rationally Designed MnSalen-Containing Metalloenzyme. ACS Catal., 2011, 1, 1083-1089;
10. Lei Liang, G. Rao, H.-L. Sun, J.-L. Zhang *, Aerobic Oxidation of Primary Alcohols Catalyzed by Copper Salts and Catalytically Active m-Hydroxyl-Bridged Trinuclear Copper Intermediate. Adv. Synth. Catal., 2010, 352, 2371-2377;
11. J.-L. Zhang , D.K. Garner, Lei Liang, D. A. Barrios, Y. Lu*, Chem. Eur. J., 2009, 15, 7481-7489;
12. Lei Liang, Zhengkai Li, Xiangge Zhou, Pyridine N-Oxides as Ligands in Cu-Catalyzed N-Arylation of Imidazoles in Water, Org. Lett., 2009, 11, 3294-3297;
